Zymogen granule fraction Calf

Creator:
Green, L
Palade, George E
Published/Created:
New Haven, CT
Yale University School of Medicine
2/2/1967
Physical Description:
3.25 in. x 4 in.
Notes:
3.25 in. x 4 in. Lantern Slides
Original Magnification: x2,000
This study demonstrated directly that the enzyme and proenzyme composition of proteins in pancreatic juice collected from an indwelling catheter in the bovine pancreatic duct correlated exactly with the protein composition obtained from lysed purified bovine zymogen granules. Subsequent studies showed that pancreatic digestive enzymes and proenzymes were secreted from the pancreas in parallel. In other words, each granule must contain, on average, the same composition of secretory proteins. This hypothesis was later directly tested by immuno-EM localization of trypsinogen and other secretory proteins in all zymogen granules in the bovine pancreas.
Topics:
Zymogen granule fraction
Topics:
Jamieson, James D
Genre:
transmission electron micrograph
Format:
Image
Content Type:
Prints & Photographs
Rights:
The use of this image may be subject to the copyright law of the United States (Title 17, United States Code) or to site license or other rights management terms and conditions. The person using the image is liable for any infringement
Yale Community Only
Access Restrictions:
Public
Yale Collection:
Yale University School of Medicine, Department of Cell Biology
Digital Collection:
George E. Palade Electron Microscopy Slide Collection
Citation:
See Greene, L. J., C.H. Hirs, and G.E. Palade. 1963. On the protein composition of bovine pancreatic zymogen granules. J. Biol. Chem. 238:2054-2070.
OID:
15817987
PID:
digcoll:2795432