New Haven, CT Yale University School of Medicine 10/27/1954
3.25 in. x 4 in.
3.25 in. x 4 in. Lantern Slides Original Magnification: x13,000 Intracisternal granules with an electron density equal to that of zymogen granules are found in the RER cisternae of animals fed after starvation or after intense in vitro stimulation with secretagogues. They may reflect the Unfolded Protein Response following rapid synthesis of proteins that outstrips the ability of the quality control system to keep up with folding of proteins for export from the RER.
Guinea Pig Pancreas Morphology
Jamieson, James D
transmission electron micrograph
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Yale University School of Medicine, Department of Cell Biology
George E. Palade Electron Microscopy Slide Collection
See Palade, G.E. 1956. Intracisternal granules in the exocrine cells of the pancreas. J. Biochem. Biophys. Cytol. 2:417-422.
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