3.25 in. x 4 in. Lantern Slides Original Magnification: x48,000 Images such as these indicated that secretory granules closely and selectively approach the apical membrane of the pancreatic acinar cell where exocytosis takes place, fuse with the apposed membrane, and release the content of secretory proteins into the acinar lumen without broaching the intracellular environment. The resulting omega figure is transitory, suggesting that the excess granule membrane is retrieved/recycled. Note the actin coat around the newly inserted granule membrane. The reference below expands on this observation 33 years later.
Jamieson, James D
transmission electron micrograph
Prints & Photographs
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Yale University School of Medicine, Department of Cell Biology
George E. Palade Electron Microscopy Slide Collection
See Valentijn, K.M., F.D. Gumkowski and J.D. Jamieson. 1999. The subapical actin cytoskeleton regulates secretion and membrane retrieval in pancreatic acinar cells. J. Cell Science. 112:81-96.
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