Exocytosis Rat Pancreas the classic electron micrograph

Creator:
Palade, George E
Published/Created:
New Haven, CT
Yale University School of Medicine
1/29/1960
Physical Description:
3.25 in. x 4 in.
Notes:
3.25 in. x 4 in. Lantern Slides
Original Magnification: x48,000
Images such as these indicated that secretory granules closely and selectively approach the apical membrane of the pancreatic acinar cell where exocytosis takes place, fuse with the apposed membrane, and release the content of secretory proteins into the acinar lumen without broaching the intracellular environment. The resulting omega figure is transitory, suggesting that the excess granule membrane is retrieved/recycled. Note the actin coat around the newly inserted granule membrane. The reference below expands on this observation 33 years later.
Topics:
Exocytosis
Topics:
Jamieson, James D
Genre:
transmission electron micrograph
Format:
Image
Content Type:
Prints & Photographs
Rights:
The use of this image may be subject to the copyright law of the United States (Title 17, United States Code) or to site license or other rights management terms and conditions. The person using the image is liable for any infringement
Yale Community Only
Access Restrictions:
Public
Yale Collection:
Yale University School of Medicine, Department of Cell Biology
Digital Collection:
George E. Palade Electron Microscopy Slide Collection
Citation:
See Valentijn, K.M., F.D. Gumkowski and J.D. Jamieson. 1999. The subapical actin cytoskeleton regulates secretion and membrane retrieval in pancreatic acinar cells. J. Cell Science. 112:81-96.
OID:
15817840
PID:
digcoll:2795265